Aconabolics, LLC

Specializing in the synthesis isotopically labeled organic acids, ketoacids, and amino acids for pharmaceutical/materials research and metabolic analysis. Our proprietary chemical reaction pathways enables the generation of both known and non-fermentable novel metabolites. Major products include isotopic and structural isomers of biochemical intermediates and analogs.

Recent News from Aconabolics

The Research

Early detection of cancer and bacterial infections saves lives; an emerging technology that enables rapid diagnoses of these conditions is called metabolic flux analysis. We have developed synthetic techniques that enable this technology by producing the necessary chemical reagents. These required molecules (13C-labelled metabolites) are highly specialized and challenging to produce, with some currently costing hundreds of dollars for an amount less than a grain of sand. Based on a decade of research experience and nearly a million dollars in research funding from agencies including NSF and NASA, we have developed the technology to directly replicate a fundamental biological pathway to these intermediates that avoids costly enzymes or fermentation. These techniques decrease the synthetic costs of the labelled metabolites by over an order of magnitude.​

MARKET

Due to the increasing view that many cancers can be classified as metabolic disorders, as well as the greatly enhanced recognition of the importance of the GI microbiome to health, the need for compounds that allow metabolic analysis is increasing. Coupled with advances in the resolution power of mass spectral analysis and magnetic resonance imaging, we foresee this being an opportune time to provide 13C-metabolites at lower cost with a vastly expanded library of products. The current market for stable isotopes is valued at 320 million US$ (2018, MarketWatch.com) and is expected to reach 400 million by 2025. We are seeking to partner with academic, industrial, and healthcare institutions on the front line of cancer research to expand the technology to the diagnosis of rare cancers and metabolic disorders.

Contact us to find out more about aconabolics.

Meet our executive Team:

Dr. Greg Springsteen, Ph.D., is a Henry Keith and Ellen Hard Townes Professor of Chemistry at Furman University. His work has been published in top international science journals and brought in over $750,000 in funding from NSF and NASA. He was named one of eight national Dreyfus Scholars in 2018.

Trent Stubbs is a graduate of at Furman University with a degree in biochemistry . He is president of Furman’s chapter of the American Chemical Society, a Furman Fellow, the founder of the Berea house service organization, and a Furman University Bell Tower Scholar.